The central dogma of biology defines the flow of genetic information: It describes how proteins are made from mRNA templates, which are in turn made from DNA. Exporting the mRNA from inside the ...

A new review synthesizes preclinical and clinical evidence showing that lipid nanoparticle biodistribution, mRNA persistence, ...

Researchers found that storage buffers alter mRNA-LNP structure, stability, and delivery. Tris improved potency after freezing and thawing, while citrate enhanced delivery during refrigerated storage ...

The popularity of mRNA-based therapeutics has surged over the past few years. To ensure the safety of these treatments, scientists need to analyze the characteristics of the manufactured molecules, ...

Researchers at IBM and Moderna have successfully used a quantum simulation algorithm to predict the complex secondary protein structure of a 60-nucleotide-long mRNA sequence, the longest ever ...

A research team led by Director Kim V. Narry at the Center for RNA Research within the Institute for Basic Science (IBS) has discovered compact viral RNA elements that can make mRNA more stable and ...

A trio of common amino acids may hold the key to unlocking far more powerful gene therapies. Researchers found that adding them to lipid nanoparticles can boost mRNA delivery up to 20-fold and push ...

Messenger ribonucleic acid (mRNA)-based therapeutics and the potential of mRNA as a treatment for various conditions has been researched for decades. A key challenge remains finding a delivery system ...

The treatment can reprogram immune cells that have been corrupted by the cancer, strengthening the body’s ability to attack.